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Mir-10 microRNA precursor family
The miR-10 microRNA precursor is a short non-coding RNA gene involved in gene regulation. It is part of an RNA gene family which contains miR-10, miR-51, miR-57, miR-99 and miR-100. miR-10, miR-99 and miR-100 have now been predicted or experimentally confirmed in a wide range of species. ((MIPF0000033 ), (MIPF0000025 )) mir-51 and mir-57 have currently only been identified in the nematode ''Caenorhabditis elegans'' ((MIPF0000268 ), (MIPF0000271 )). microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.
== Species distribution ==
The presence of miR-10 has been detected in a diverse range of bilaterian animals. It is one of the most widely distributed microRNAs in animals, it has been identified in numerous species including human, dog, cat, horse, cow, guinea pig, mouse, rat, common marmoset (''Callithrix jacchus''), common chimpanzee (''Pan troglodytes''), rhesus monkey (''Macaca mulatta''), Sumatran orangutan (''Pongo abelii''), northern greater galago (''Otolemur garnettii''), grey short-tailed opossum (''Monodelphis domestica''), northern treeshrew (''Tupaia belangeri''), European rabbit (''Oryctolagus cuniculus''), African bush elephant (''Loxodonta africana''), nine-banded armadillo (''Dasypus novemcinctus''), European hedgehog (''Erinaceus europaeus''), lesser hedgehog tenrec (''Echinops telfairi''), zebra finch (''Taeniopygia guttata''), chicken, platypus (''Ornithorhynchus anatinus''), Western clawed frog (''Xenopus tropicalis''), Carolina anole (''Anolis carolinensis''), zebrafish (''Danio rerio''), Japanese pufferfish (''Fugu rubripes''), green spotted pufferfish (''Tetraodon nigroviridis''), Japanese killifish (''Oryzias latipes''), three-spined stickleback (''Gasterosteus aculeatus''), Florida lancelet (''Branchiostoma floridae''), California purple sea urchin (''Strongylocentrotus purpuratus''), 12 different species of fruit fly (''Drosophila''), Western honey bee (''Apis mellifera''), mosquito (''Anopheles gambiae''), red flour beetle (''Tribolium castaneum''), the nematode ''Caenorhabditis elegans'', owl limpet (''Lottia gigantea''), starlet sea anemone (''Nematostella vectensis'') and the blood fluke ''Schistosoma japonicum''. In some of these species the presence of miR-10 has been shown experimentally, in others the genes encoding miR-10 have been predicted computationally.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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